Long setup, big table presence and long gameplay usually means I won't get the game out often.... but I really don't care when the game is as good and fun to play as Andromed'as Edge. The Expansion with the solo mode make it stay on the table for weeks, to play over and over trying different faction against different Automas (Unity the name). Don't be scared by this big game, the gameplay is very intuitive and satisfying, and the iconography is perfect.
Only cons for me are "some components choices" designers made when making the retail and delux versions. Some are goos in both, some are bad in both.